Clz Side effects

• Side effects of Clz in details
• Clz contraindications
• Clz reviews

What are the possible side effects of Clz?

Get emergency medical help if you have any signs of an allergic reaction to Clz: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Clz can cause diarrhea, which may be severe or lead to serious, life-threatening intestinal problems. If you have diarrhea that is watery or bloody, stop using Clz and call your doctor.

Call your doctor at once if you have:

• any change in bowel habits;

• little or no urination;

• a metallic taste in your mouth;

• signs of inflammation in your body - swollen glands, flu symptoms, easy bruising or bleeding, severe tingling or numbness, muscle weakness, upper stomach pain, jaundice (yellowing of the skin or eyes), chest pain, new or worsening cough with fever, trouble breathing; or

• severe skin reaction- fever, sore throat, swelling in your face or tongue, burning in your eyes, skin pain, followed by a red or purple skin rash that spreads (especially in the face or upper body) and causes blistering and peeling.

Common Clz side effects may include:

• nausea, vomiting, stomach pain;

• mild skin rash; or

• vaginal itching or discharge;

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Side effects of Clz in details

Clinical Trials Experience

Because clinical trials are conducted under widely varying conditions, adverse reaction rates observed in the clinical trials of a drug cannot be directly compared to rates in the clinical trials of another drug and may not reflect the rates observed in clinical practice.

A total of 439 subjects with mild to moderate acne vulgaris were treated once daily for 12 weeks with Clz Foam.

The incidence of adverse reactions occurring in ≥1% of the subjects in clinical trials comparing Clz Foam, and its vehicle is presented in Table 1.

Table 1: Adverse Reactions Occurring in ≥1% of Subjects

Adverse Reactions	Number (%) of Subjects
	Clz Foam	Vehicle Foam
	N = 439	N = 154
Headache	12 (3%)	1 (1%)
Application site burning	27 (6%)	14 (9%)
Application site pruritus	5 (1%)	5 (3%)
Application site dryness	4 (1%)	5 (3%)
Application site reaction, not otherwise specified	3 (1%)	4 (3%)

In a contact sensitization study, none of the 203 subjects developed evidence of allergic contact sensitization to Clz Foam.

Postmarketing Experience

The following adverse reactions have been identified during post approval use of Clz Foam: application site pain, application site erythema, diarrhea, urticaria, abdominal pain, hypersensitivity, rash, abdominal discomfort, nausea, seborrhea, application site rash, dizziness, pain of skin, colitis (including pseudomembranous colitis), and hemorraghic diarrhea. Because these reactions are reported voluntarily from a population of uncertain size, it is not always possible to reliably estimate their frequency or establish a causal relationship to drug exposure.

Abdominal pain and gastrointestinal disturbances, as well as gram-negative folliculitis, have also been reported in association with the use of topical formulations of Clz.

Orally and parenterally administered Clz have been associated with severe colitis, which may end fatally.

What is the most important information I should know about Clz?

• Clz solution is for external use only. Avoid contact with the eyes as burning or irritation can occur. If contact occurs with the eyes or sensitive surfaces (eg, mucous membranes, scraped skin), wash the area with cool tap water.
• Clz solution may cause harm if it is swallowed. If you may have taken it by mouth, contact your or emergency room right away.
• Clz solution has an unpleasant taste. Use caution when applying Clz solution around the mouth.
• Several weeks may pass before you see improvement in your acne. Continue using Clz solution for the full time recommended by your doctor. If your acne does not improve or gets worse, check with your doctor.
• Be sure to use Clz solution for the full course of treatment. If you do not, the medicine may not clear up your infection completely. The bacteria could also become less sensitive to this or other medicines. This could make the infection harder to treat in the future.
• If severe diarrhea, stomach pain or cramping, or bloody stools develop during treatment or within several months after treatment with Clz solution, check with your doctor or pharmacist right away. Do not treat it without first checking with your doctor.
• Clz solution should not be used in CHILDREN younger than 12 years old; safety and effectiveness in these children have not been confirmed.
• PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Clz solution while you are pregnant. It is not known if Clz solution is found in breast milk. Do not breast-feed while taking Clz solution.

Clz contraindications

You should not use this medication if you are allergic to Clz or lincomycin (Bactramycin, L-Mycin, Lincocin).

Do not take Clz together with erythromycin (E.E.S., EryPed, Ery-Tab, Erythrocin, Pediazole, and others).

Before using Clz, tell your doctor if you have kidney disease, liver disease, an intestinal disorder such as colitis or Crohn's disease, or a history of asthma, eczema, or allergic skin reaction.

Take this medicine for the full prescribed length of time. Your symptoms may improve before the infection is completely cleared. Skipping doses may also increase your risk of further infection that is resistant to antibiotics. Clz will not treat a viral infection such as the common cold or flu.

Antibiotic medicines can cause diarrhea, which may be a sign of a new infection. If you have diarrhea that is watery or bloody, stop taking Clz and call your doctor. Do not use anti-diarrhea medicine unless your doctor tells you to.

To be sure this medication is not causing harmful effects, your blood may need to be tested often. Your kidney or liver function may also need to be tested. Visit your doctor regularly.

If you need surgery, tell the surgeon ahead of time that you are using Clz. You may need to stop using the medicine for a short time.

References

1. European Chemicals Agency - ECHA. "Clindamycin: The information provided here is aggregated from the "Notified classification and labelling" from ECHA's C&L Inventory. ". https://echa.europa.eu/information-o... (accessed September 17, 2018).
2. HSDB. "CLINDAMYCIN". https://toxnet.nlm.nih.gov/cgi-bin/s... (accessed September 17, 2018).
3. NCIt. "Clindamycin: NCI Thesaurus (NCIt) provides reference terminology for many systems. It covers vocabulary for clinical care, translational and basic research, and public information and administrative activities.". https://ncit.nci.nih.gov/ncitbrowser... (accessed September 17, 2018).

Reviews

The results of a survey conducted on ndrugs.com for Clz are given in detail below. The results of the survey conducted are based on the impressions and views of the website users and consumers taking Clz. We implore you to kindly base your medical condition or therapeutic choices on the result or test conducted by a physician or licensed medical practitioners.

User reports

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Information checked by Dr. Sachin Kumar, MD Pharmacology